Joint penetration of augmentin
For patients undergoing joint replacement surgery, only one bone sample is most in combination with mg clavulanic acid (Augmentin; GlaxoSmithKline.
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MATERIALS AND METHODS
In this paper we have studied the penetration of Augmentin® into bone and synovial fluid. Augmentin is During the operation, the hip joint was aspirated prior.
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Description:Scale terms were included to describe the equilibrium concentration ratios between cancellous bone and serum Fcancellous and between cortical bone and serum Fcortical. We present the first evaluation of the bone penetration of a beta-lactam by population pharmacokinetics and pharmacodynamic profiling via Monte Carlo simulations. Additionally, we provided the expected PK-PD breakpoints for various potential scenarios of the distribution of drug and bacteria in bone. The second objective was to develop a PK model which describes the time course of the amoxicillin and clavulanic acid concentrations in bone as well as the drug exposure in bone relative to that in serum. For both drugs, the concentrations were lower in cortical and cancellous bone than in serum. To reduce the incidence of infections after orthopedic surgery, perioperative prophylaxis is standard practice.
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